• Production Code: STV421
• Original Air Date: 4/15/98
• Teleplay by: Lisa Klink
• Story by: Jimmy Diggs & Steve J. Kay
• Directed by: Victor Lobl
• Guest Cast:
  • Jeff Austin as Allos
  • Kevin McCorkle as the Alien Captain

The crew is mystified when Captain Janeway begins an important, though highly secretive, operation in response to a strange subspace disturbance. Chakotay finally compels her to tell the crew so that they may help. Janeway explains that Voyager has detected a dangerous, unstable substance called the Omega. The molecule has the power to destroy space and Starfleet's highly classified operating order is to destroy the Omega whenever it is encountered. Seven of Nine speaks out to say that the Borg believe the Omega can be captured and neutralized for study, which puts her in conflict with Janeway's Starfleet mission.